Favignana is connected to Sicily by two harbors: Trapani and Marsala

From Trapani you can sail on hydrofoils that depart very frequently from 7.00 to 19.30 hours. From Trapani you can also use the ferries that can carry over to the passengers, the vehicles but the race is much less frequent. From the port of Marsala you can only use the hydrofoil service.

The company performs all services 
www.libertylines.it

The nearest airports are:
Trapani / Birgi is about 30 km from the port of Trapani and about 15 Km from the port of Marsala.
Palermo / Falcone Borsellino is about 70 km from the port of Trapani and about 60 from the port of Marsala.